{"id":3315,"date":"2026-04-23T15:12:44","date_gmt":"2026-04-23T18:12:44","guid":{"rendered":"https:\/\/kpi.pt\/?p=3315"},"modified":"2026-04-23T15:12:44","modified_gmt":"2026-04-23T18:12:44","slug":"bruxism-as-a-window-into-systemic-and-molecular-dysregulation","status":"publish","type":"post","link":"https:\/\/kpi.pt\/index.php\/2026\/04\/23\/bruxism-as-a-window-into-systemic-and-molecular-dysregulation\/","title":{"rendered":"Bruxism as a window into systemic and molecular dysregulation"},"content":{"rendered":"\n<p>Bruxism should no longer be viewed solely as a peripheral oral condition. Increasing evidence supports its association with sleep disturbances, particularly insomnia with short sleep duration, a phenotype linked to heightened cardiometabolic risk.<br>At the molecular level, microRNAs (miRNAs) \u2014 key post-transcriptional regulators of gene expression \u2014 are emerging as critical mediators between sleep disruption and systemic disease.<br>Recent findings indicate that even acute sleep deprivation may alter miRNA expression profiles, suggesting a rapid biological response with potential downstream effects on inflammation, metabolic regulation, and cardiovascular pathways.<br>Clinically, this systemic imbalance may manifest as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tooth wear and fractures<\/li>\n\n\n\n<li>Implant complications<\/li>\n\n\n\n<li>Temporomandibular joint degeneration<\/li>\n\n\n\n<li>Myofascial pain<br>\ud83d\udc49 These manifestations should be interpreted within a broader biopsychosocial and molecular framework, rather than as isolated dental findings.<br>A multidisciplinary, translational approach, integrating Dental Sleep Medicine, molecular biology, and personalized medicine, is essential to move from symptom management to mechanism-based care.<br>At Klinicaperioimplantologica Rainha D. Leonor (KPI), our research focuses on identifying salivary miRNA signatures associated with insomnia phenotypes, aiming to develop novel biomarkers for cardiometabolic risk stratification.<br>Sleep is a regulator of gene expression \u2014 and bruxism may be one of its clinical signals.<br>\ud83d\udcd6 DOI: 10.1016\/j.sleepx.2026.100184<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Bruxism should no longer be viewed solely as a peripheral oral condition. Increasing evidence supports its association with sleep disturbances, particularly insomnia with short sleep duration, a phenotype linked to heightened cardiometabolic risk.<br \/>\nAt the molecular level, microRNAs (miRNAs) \u2014 key post-transcriptional regulators of gene expression \u2014 are emerging as critical mediators between sleep disruption and systemic disease.<\/p>\n","protected":false},"author":1,"featured_media":3316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bruxism as a window into systemic and molecular dysregulation - KLINICA PERIOIMPLANTOLOGICA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kpi.pt\/index.php\/2026\/04\/23\/bruxism-as-a-window-into-systemic-and-molecular-dysregulation\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bruxism as a window into systemic and molecular dysregulation - KLINICA PERIOIMPLANTOLOGICA\" \/>\n<meta property=\"og:description\" content=\"Bruxism should no longer be viewed solely as a peripheral oral condition. Increasing evidence supports its association with sleep disturbances, particularly insomnia with short sleep duration, a phenotype linked to heightened cardiometabolic risk. 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